Abstract:

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)  are two kinds of severe drugs adverse reactions,  which can seriously threaten the life of the patients. The clinical symptoms of the two diseases are very similar, and they are cross sometimes in clinic. The common symptoms of the two diseses are general malaise, high fever, skin herpes and spot, and often accompanied by mucosal damage and eye injury. Clinical treatment of the eye injury caused by SJS and TEN is difficult, blindness and poor prognosis are common if there is no timely treatment. The main pathogenesis is the interaction between Fas receptors and soluble Fas ligands secreted by mononuclear cells in the peripheral blood, so that the apoptosis of keratinocytes is rapidly and the  epidermal cells is damaged, and the clinical symptoms are obvious. The clinical treatment methods include general treatment (system support treatment, skin and mucosal secretions or pseudo membrane cleaning, and Tacrolimus) and specific treatment (corticosteroids, cyclophosphamide) and the treatment of eye damage (depending on the condition to give amniotic membrane transplantation and conjunctival flap covering, corneal transplantation, artificial cornea and ocular surface reconstruction surgery).